This street received its name in 1907, uniting streets formerly known as Nebraska Street, 8th Street, Bedford Street, Conover Street, and G Street. (There had been an Oregon Street in the 1895 Seattle Tide Lands plat in which Nebraska Street was created, but it became Spokane Street and Chelan Avenue in the same 1907 change.)
S Oregon Street begins in West Seattle as SW Oregon Street at the Emma Schmitz Memorial Overlook on Beach Drive SW and goes two blocks east to Me-Kwa-Mooks Park at 56th Avenue SW. It briefly resumes at 52nd Avenue SW and goes two blocks east to 51st Avenue SW, then begins again in earnest at 50th Avenue SW, going nearly a mile east to the West Seattle Stadium at 35th Avenue SW, part of the stretch between there and Fauntleroy Way SW being footpath and stairway. East of the West Seattle Golf Course, it goes around 175 feet to 26th Avenue SW and the Delridge Playfield, and on the other side of the playfield serves as a short connector between Delridge Way SW and 23rd Avenue SW.
S Oregon Street resumes east of the Duwamish Waterway at a shoreline street end and goes ¼ mile east to E Marginal Way S. It then serves as short connectors between Diagonal Avenue S and Denver Avenue S and between 7th Avenue S and Airport Way S.
East of Interstate 5, on Beacon Hill, S Oregon Street begins again at 10th Avenue S and goes ⅓ of a mile east to 15th Avenue S and S Columbian Way. It picks up again in the Rainier Valley at S Columbian Way and Martin Luther King Jr. Way S and goes ⅔ of a mile east to Genesee Park at 42nd Avenue S. East of the park, it resumes at 47th Avenue S and goes ¼ mile east to its end at 52nd Avenue S above the Lakewood Marina on Lake Washington.