Louisa Street was named for Louisa Boren Denny (1827–1916), who was 24 years old when she and her future husband David Thomas Denny (1832–1903) arrived in Seattle as part of the Denny Party. Their marriage in 1853 was the first in King County. The street name originates in the 1890 plat of the Denny-Fuhrman Addition to the City of Seattle, filed by the Dennys, Henry Fuhrman (Fuhrman Avenue E), and his wife, Carrie Fuhrman.

Daguerreotype portrait of Louisa Boren Denny, no date
Undated daguerreotype portrait of Louisa Boren Denny

Today, E Louisa Street begins at Minor Avenue E and goes a block east to Yale Avenue E. It resumes half a block east at the alley west of Eastlake Avenue E and makes it 2½ blocks before being stopped by Interstate 5 at Boylston Avenue E. Resuming in the Montlake neighborhood just west of W Montlake Place E, it then goes ¼ mile east to 25th Avenue E.

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